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:: Volume 3, Issue 3 And 4 (11-2016) ::
vacres 2016, 3(3 And 4): 39-43 Back to browse issues page
Lactococcus lactis as a live delivery vector
M Azizpour, SD Hosseini *, P Jafari, N Akbary
Razi vaccine and serum Research institute, Arak Branch, Arak, Iran.
Abstract:   (4739 Views)

Mucosal surfaces of the body provide a universal entry portal for all known and emerging infectious pathogenic microbes. Therefore, it seems that special vaccination strategies are needed for vaccines that can hinder the entry capability of pathogenic microbes through the mucosal surfaces. Lactic acid bacteria are widely used in the food industry and are presently applied as delivery vehicles in many biological investigations. Among these bacteria, Lactococcus lactis is considered as a promising candidate for mucosal live vaccines to be used as an antigen delivery vector. This is an attractive alternative and a safer vaccination strategy against the pathogens, compared to other conventional methods. In this review, we summarized the applications of L. lactis as a mucosal vector of vaccine delivery for heterologous expression of proteins and its applications in biotechnology. 

Keywords: Lactococcus lactis, Live vector, Live delivery vaccines, Mucosal vaccines.
Full-Text [PDF 439 kb]   (2290 Downloads)    
Type of Study: Review article |
Received: 2016/12/4 | Accepted: 2016/12/4 | Published: 2016/12/4
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Azizpour M, Hosseini S, Jafari P, Akbary N. Lactococcus lactis as a live delivery vector. vacres. 2016; 3 (3 and 4) :39-43
URL: http://vacres.pasteur.ac.ir/article-1-88-en.html

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