Design, Synthesis, Physicochemical and Immunological Characterization of Dendrimer-HBsAg Conjugate

Khosravy, Mohammad Sadeq; Shafiee Ardestani, Mehdi; Ahangari Cohan, Reza; Doroud, Delaram; Amini, Safieh; Momen, Seyed Bahman; Atyabi, Seyed Mohammad; Heydari, Hossien; Vahabpour, Rohollah

doi:10.18869/acadpub.vacres.1.2.24

Volume 1, Issue 2 (11-2014) vacres 2014, 1(2): 24-28 | Back to browse issues page

‎ 10.18869/acadpub.vacres.1.2.24

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Khosravy M S, Shafiee Ardestani M, Ahangari Cohan R, Doroud D, Amini S, Momen S B, et al . Design, Synthesis, Physicochemical and Immunological Characterization of Dendrimer-HBsAg Conjugate. vacres 2014; 1 (2) :24-28
URL: http://vacres.pasteur.ac.ir/article-1-42-en.html

Design, Synthesis, Physicochemical and Immunological Characterization of Dendrimer-HBsAg Conjugate

Mohammad Sadeq Khosravy

, Mehdi Shafiee Ardestani ^*

, Reza Ahangari Cohan

, Delaram Doroud

, Safieh Amini

, Seyed Bahman Momen

, Seyed Mohammad Atyabi

, Hossien Heydari

, Rohollah Vahabpour

Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Abstract: (8122 Views)

Manufacturing new Hepatitis B virus vaccines, specifically by the use of nanoparticles, is of high global interest. In this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis B virus’ surface antigen (HBsAg) was generated by conjugation with dendrimers, a low cost biodegradable and biocompatible polymer. The physicochemical properties of the conjugate were characterized by zeta potential and size distribution analyses and FT-IR spectrometry. The results confirmed the conjugation between HBsAg and the dendrimers. Immunological assays indicated that the immunogenicity of the conjugated HBsAg is more than HBsAg alone. Further investigations are required to explore the mechanisms of action and the exact immunological pathway(s) of this nanocomplex vaccine candidate.

Keywords: HBsAg, Dendrimers, Vaccine, Conjugate.

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Type of Study: Original article |
Received: 1970/01/1

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