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:: Volume 1, Issue 1 (Vaccine Research 2014) ::
vacres 2014, 1(1): 25-27 Back to browse issues page
Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran
Pooneh Rahimi *, Mohammad Reza Shirzadi, Firouzeh Farahtaj, Vida Fallahian, Jamal Sharifian, Nader Howaizi, Mansour Shamsipour, Rouhollah Vahabpour
Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran
Abstract:   (31686 Views)

  Background: Despite the effective pre- and post-exposure treatments, at least 60,000 deaths from rabies occur worldwide every year. Post-exposure treatment is considered as one of the most significant measures for preventing human deaths in exposed individuals. The 2-1-1 rabies post-exposure treatment schedule known as Zagreb regimen is an abbreviated immunization plan in which a tissue culture rabies vaccine is administered intramuscularly at two sites on day 0 and at one site on days 7 and 21. Objectives: In this study the efficacy of rabies vaccine administration under Zagreb regimen in an Iranian group of patients attending Pasteur Institute of Iran was evaluated. Methods: Rabies neutralizing antibody titer was measured in 75 serum samples collected from 25 volunteers receiving post exposure treatment by rapid fluorescent focus inhibition test (RFFIT), and ELISA. Results: All patients were negative for rabies antibody in both ELISA and FRRIT tests on day 0 . A satisfactory rabies virus antibody response with the titer of ≥0.5 IU/ml was detected in all patients on day 21 and two weeks after the completion of vaccination (day 35). Conclusions: Rabies immunization with rabies Vero-cell vaccine (PVRV) under the 2-1-1 schedule (Zagreb regimen) could result in an adequate immune response without any adverse effect. However a more comprehensive comparative study is underway to confirm these findings . Vac Res , 2014, 1 (1): 26-28

Keywords: Zagreb regimen, PVRV, Rabies vaccines, Post-exposure prophylaxis
Full-Text [PDF 418 kb]   (2273 Downloads)    
Type of Study: Original article |
Received: 2013/09/16 | Accepted: 2014/05/25 | Published: 2014/07/13
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Rahimi P, Shirzadi M R, Farahtaj F, Fallahian V, Sharifian J, Howaizi N, et al . Efficacy of Purified Vero Cell Rabies Vaccine (PVRV) under the Zagreb Regimen in Iran. vacres. 2014; 1 (1) :25-27
URL: http://vacres.pasteur.ac.ir/article-1-32-en.html

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