دوره 3، شماره 1 و 2 - ( 2-1395 )                   جلد 3 شماره 1 و 2 صفحات 25-21 | برگشت به فهرست نسخه ها


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Mirzaei B, Moosavi S, Babaei R, Siadat S, Farjah A, Shahrooei M. Purification and evaluation of glycerol teichoic acid from biofilm forming Staphylococcus epidermidis as a putative vaccine candidate. vacres. 2016; 3 (1 and 2) :21-25
URL: http://vacres.pasteur.ac.ir/article-1-81-fa.html
Purification and evaluation of glycerol teichoic acid from biofilm forming Staphylococcus epidermidis as a putative vaccine candidate. Vaccine Research. 1395; 3 (1 و 2) :25-21

URL: http://vacres.pasteur.ac.ir/article-1-81-fa.html


چکیده:   (5170 مشاهده)

Introduction: Biofilm forming Staphylococcus epidermidis is a main causative agent of infections related to medical devices. Purification and evaluation of Gly-TA polysaccharide from a biofilm-forming S. epidermidis as a putative vaccine candidate were the main goals of the current study. Methods: Taking advantage of size exclusion chromatography procedure, glycerol teichoic acid (Gly-TA) was purified from the above-mentioned strain and biochemical analyses including, Fourier Transform Infrared spectroscopy (FTIR) and Proton Nuclear Magnetic Resonance spectroscopy (H1-NMR) were conducted for the recovered polysaccharide. Results: Following PCR confirmation of a S. epidermidis strain, Gly-TA was extracted and its biochemical compositions (i.e. N-acetyl glucose amine residues) were obtained. Conclusion: It is envisaged that Gly-TA polysaccharide could be considered as a putative vaccine to inhibit formation of biofilm by S. epidermidis.

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نوع مطالعه: Short communication |
دریافت: 1395/6/31 | پذیرش: 1395/6/31 | انتشار: 1395/6/31

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