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Decades after the production of recombinant vaccines, the production of large scale and commercial use of such vaccines has become an important issue in the academic community. Newcastle disease is an infectious and highly contagious viral disease that causes diseases with different virulence and high infectivity in birds, especially chickens. Newcastle disease imposes severe economic losses on the poultry industry, and as a result, tackling it is always a priority for all countries of the world. In this regard, many vaccines have been produced, some of which are commercialized and some of which are in the testing phase. Given the economic importance of controlling Newcastle disease, the production of recombinant vaccines against the disease has been one of the hottest areas in the history of recombinant vaccines. Over the past three decades, many laboratory studies have been conducted to produce recombinant Newcastle disease vaccines on various platforms, which in many cases have yielded promising results. This article reviews the literature on the production of recombinant Newcastle disease vaccines. In this regard, while introducing Newcastle disease and its causative agent, the basics of producing recombinant vaccines and production platforms are explained. The following are some studies that have shown promising results for the production of the recombinant Newcastle disease vaccine. At the end of this article, while summarizing, areas for future research are introduced.

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