دوره 6، شماره 2 - ( 9-1398 )                   جلد 6 شماره 2 صفحات 36-23 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Antony J. Immunobiological Correlates of SIV Vaccine Vectors and Macaque Tropism. vacres 2019; 6 (2) :23-36
URL: http://vacres.pasteur.ac.ir/article-1-190-fa.html
Immunobiological Correlates of SIV Vaccine Vectors and Macaque Tropism. Vaccine Research. 1398; 6 (2) :23-36

URL: http://vacres.pasteur.ac.ir/article-1-190-fa.html


چکیده:   (8135 مشاهده)
The field of HIV vaccines received a “boost” with around 30% protection obtained in the RV144 randomized, double-blind, efficacy trial in Thailand. Currently, 560 clinical trials in HIV vaccine development are registered as complete and results are expected from several of these studies. The modest success attained at this time may be attributed to early attempts at identifying an animal model to test vaccine efficacy. Macaque models of HIV-1 infection have revealed viral infection, transmission, pathogenesis, and prevention. Identification of simian immunodeficiency virus (SIV) and its related strains served as the macaque counterpart of HIV and through genetic engineering, enabled chimera development that explored how macaques respond to a human antigen as well. Along with understanding viral infection, it is worth exploring the genetic repertoire of macaques for determining how the major histocompatibility complex and anti-retroviral restriction factors offer barriers to viral replication.
متن کامل [PDF 558 kb]   (896 دریافت)    
نوع مطالعه: Review article | موضوع مقاله: Immunologic studies and animal models
دریافت: 1399/1/10

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به Vaccine Research می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 All Rights Reserved | Vaccine Research

Designed & Developed by : Yektaweb

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.