Vaccine Research
Vaccine Research
vacres
Medical Sciences
http://vacres.pasteur.ac.ir
1
admin
2383-2819
2423-4923
10.61186/vacres
en
jalali
1393
8
1
gregorian
2014
11
1
1
2
online
1
fulltext
en
Design, Synthesis, Physicochemical and Immunological Characterization of Dendrimer-HBsAg Conjugate
Original article
Original article
<span style="FONT-FAMILY: "Times New Roman",serif FONT-SIZE: 10pt mso-fareast-font-family: Garamond mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: AR-SA">Manufacturing new Hepatitis B virus vaccines, specifically by the use of nanoparticles, is of high global interest. In this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis B virus’ surface antigen (HBsAg) was generated by conjugation with dendrimers, a low cost biodegradable and biocompatible polymer. The physicochemical properties of the conjugate were characterized by zeta potential and size distribution analyses and FT-IR spectrometry. The results confirmed the conjugation between HBsAg and the dendrimers. Immunological assays indicated that the immunogenicity of the conjugated HBsAg is more than HBsAg alone. Further investigations are required to explore the mechanisms of action and the exact immunological pathway(s) of this nanocomplex vaccine candidate.</span>
HBsAg, Dendrimers, Vaccine, Conjugate.
24
28
http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-27-14&slc_lang=en&sid=1
Mohammad Sadeq
Khosravy