en Other Other پژوهشي Research <pre> <span style="font-size:10pt"><span style="tab-stops:375.6pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:9.5pt">Introduction: </span></b><span style="font-size:9.5pt">Vaccination against severe acute respiratory syndrome coronavirus (SARS-CoV-2) plays a major role in the global fight against the COVID-19 pandemic. However, the availability of and access to a safe COVID-19 vaccine alone may not be sufficient to curb the epidemic. Vaccine hesitancy&mdash;including delays and refusals&mdash;remains a major obstacle to achieving herd immunity. This study aimed to investigate public attitudes toward the COVID-19 vaccine. <b>Methods: </b>This descriptive and analytical study was conducted on 1,544 individuals over 30 years of age in South Khorasan Province, selected via convenience sampling through the SIB system. Data were collected using a questionnaire to measure attitudes, administered via telephone interviews. Statistical analyses included mean and standard deviation, frequency and percentage distributions, chi-square tests, independent samples t-tests, and logistic regression analyses, with a significance level set at <i>P</i> < 0.05. <b>Results: </b>The findings revealed variations in vaccination rates across demographic categories, including gender, education level, marital status, occupation, and place of residence. Key factors influencing hesitancy included doubts about the accuracy of vaccine-related information, strong fears of vaccination, and the belief that individuals who had not contracted COVID-19 were naturally resistant and did not require vaccination. <b>Conclusion:</b> Public attitudes, doubts, and concerns regarding the COVID-19 vaccine significantly impact vaccination coverage rates. Therefore, understanding the reasons behind vaccine hesitancy is essential for designing targeted interventions.</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span> </pre> Covid-19 disease, Covid-19 vaccine, Attitude 39 43 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-7940-1&slc_lang=en&sid=1 Zahra Vahdaninya vahdane@bums.ac.ir 0000-0003-3119-8200 No Social determinants research center, Birjand university of Medical Science , Birjand, Iran fatemeh salmani salmany_fatemeh@bums.ac.ir 0000-0001-6781-3899 No Department of Epidemiology and Biostatics, school of health , social determinants research center, Birjand university of Medical Science , Birjand, Iran Fatemeh khosravy fkhosravi4927@bums.ac.ir 0000-0002-8655-3938 No Social determinants research center, Birjand university of Medical Science , Birjand, Iran Fatemeh Baghernezhad hesary ftbagher@gmail.com 0000-0002-2977-4320 Yes department of heath education and promotion . school of health , social determinants research center, Birjand university of Medical Science , Birjand, Iran