Vaccine Research

en Acceptance of COVID-19 Vaccination at Different Hypothetical Efficacy and Safety Levels in Nigeria: A Cross-Sectional Web-based Survey Infectious diseases Infectious diseases Original article Original article Introduction: Vaccine hesitancy is a global phenomenon and vaccination efforts against the Coronavirus Disease 2019 (COVID-19) pandemic may be hampered by it. This study assessed the acceptance rate of COVID-19 vaccination at different hypothetical efficacy and safety levels in Nigeria. Methods: This web-based study was conducted among a selected Nigerian population between the month of February and May 2021 using an online self-administered structured questionnaire hosted by Survey Monkey. WhatsApp, Twitter and Facebook were used to disseminate the invitation to take the poll. Results: The finding of this study revealed that a larger proportion of the participants were males (53.9%), within the age group of 31-40 years (25.6%) and earn an average income of less than $500 per month. Individuals between the ages of 21 and 30 years and 31 to 40 years showed the highest levels of acceptability for the COVID-19 vaccine at 95% efficacy and 5% adverse effects. The older age group (>51 years and above) had the least vaccine acceptance rate (3.3%) at 75% vaccine efficacy and 20% side effect. Respondents who held the belief that vaccinations are essential for their health had a higher chance to accept the COVID-19 vaccine with OR: 0.76; 50%CI (0.00-0.00), OR:  95%CI (0.000-0.000), OR: 1.23; 95%CI (0.193-7.860) and OR: 0.696; 95%CI (0.048-10.047) based on religion, the occurrence of diabetes, pulmonary disease, and Hypertension, respectively. Conclusion: The results of this research indicate that vaccine acceptance rates are negatively correlated with participants' ages. Acceptance, COVID-19, Efficacy, Nigeria, safety, Vaccine 39 47 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-7567-1&slc_lang=en&sid=1 Richard Akele akelerichard@gmail.com 0000-0003-2006-0820 No Department of Biomedical Science, School of Applied Science, University of Brighton, London, United Kingdom Seyi Enitan enitans@babcock.edu.ng 0000-0001-5993-7920 Yes Department of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Nigeria. Esther Adejumo adejumoe@babcock.edu.ng 0000-0001-5825-4247 No Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Nigeria. Eyiuche Ezigbo eyiuche.ezigbo@unn.edu.ng No Department of Medical Laboratory Sciences, Faculty of Health Sciences & Technology University of Nigeria, Enugu State Nigeria. Abiodun Durosinmi durosinmiemmanuela@gmail.com 0000-0002-5382-5108 No Department of Medical Laboratory Science, State Hospital, Ijebu Ode, Ogun, Nigeria. Grace Itodo graceitodo6@gmail.com No Department of Medical Microbiology, Federal Medical Centre, Lokoja, Nigeria. Adedeji Abdulsalam abimbolaadedeji13@gmail.com No Medical Laboratory Science Department, Afe Babalola University, Ado-Ekiti, Nigeria Michael Dada dadam@babcock.edu.ng 0000-0002-0278-0579 No Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Nigeria. Okeoghene Edafetanure-Ibeh ibehmarcel02@gmail.com No Department of Environmental and Occupational Health, Texas A&M University School of Public Health, College Station, Texas, United States Oyekan Oyedoyin ifeoluwaoyekan@gmail.com 0000-0002-5306-4249 No Department of Medical Laboratory Science, State Hospital Ijebu-Ode, Ijebu-Ode, Ogun State, Nigeria Polit Yelpoji politu@unijos.edu.ng No Department of Medical Laboratory Science, Faculty of Health Sciences And Technology, University of Jos, Plateau State, Nigeria. Abah Idoko doksman999@gmail.com No Department of Hematology and Blood Group Serology, Federal College of Veterinary and Medical Laboratory Technology, Vom, Nigeria. Ogunwola Opeyemi tosinogunwola@gmail.com 0000-0001-7850-4565 No Department of Medical Laboratory Science, Bola Tinubu Health and Diagnostic Center, LASUTH, Lagos State, Nigeria. Ogbuji Nmesomachi Silviaogbuji7@gmail.com No Department of Pathology68 Nigerian Army Reference Hospital Yaba, Lagos, Nigeria. Edwin Okafor nkemjika.okafor@unn.edu.ng No Department of Medical Laboratory Sciences. University of Nigeria. Enugu Campus, Enugu, Nigeria Adesola Oyekale aooyekale@pgschool.lautech.edu.ng 0000-0002-2352-4144 No Department of Chemical Pathology, Ladoke Akintola University of Technology Ogbomoso, Oyo state Nigeria