en Humanand veterinary vaccines Humanand veterinary vaccines Short communication Short communication Vaccines are a major weapon to control the present COVID-19 pandemic. To achieve this goal, vaccines should confer a robust and long-lasting immunity against SARS-Cov-2. Breakthrough infections and waning immunity are currently observed in patients that recovered from COVID-19 as well as in the vaccinated people. Therefore, a highly effective vaccine is needed to control the present and future outbreaks. Exogenous N-acetyl-5-methoxy-tryptamine or melatonin (MLT) is well known to potentiate an effective and equilibrated immune response in a variety of situation including viral and bacterial infections and vaccines against different microbial and cancer antigens. In regard to anti-SARS-Cov-2 vaccines, beside stimulating specific IgG production as well as specific CD4+ and CD8+ T cells, exogenous MLT might also enhance specific IgA and secretory IgA in the mucosae; hence, preventing the re-infection and/or asymptomatic transmission of the virus. Thus, a study is urgently proposed to evaluate the effects of MLT administration either before or after vaccination against SARS-Cov-2 to evaluate its effect on strength, quality and duration of the immunity. Las but not least, due to its powerful antioxidant and anti-inflammatory properties, MLT administration might minimize the occurrence of adverse events after the vaccination. SARS-Cov-2, Melatonin, Immune Response , COVID-19 Vaccine 97 100 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-4823-1&slc_lang=en&sid=1 Georges Maestroni georges.maestroni@tim.it 0000-0003-3900-8088 Yes Center for Research in Medical Pharmacology, University of Insubria, Varese, Italy