en Infectious diseases Infectious diseases Original article Original article <strong>Introduction:</strong> To understand the effects of COVID-19 vaccines it would be essential to have knowledge about the effects of the disease during the time that vaccines were unavailable. Hence, we tracked the clinical outcomes of Iranian COVID-19 patients during Feb 19th till May 1st 2020 by a longitudinal follow-up study of patients discharged from a university hospital in Iran. <strong>Methods:</strong> Demographic, clinical, and paraclinical data (chest CT scan imaging, and RT-PCR tests) of 139 patients were collected at the admission time. Preliminary clinical, radiological, laboratory, treatment information, and follow up results were extracted and collected from patients&#39; records. <strong>Results:</strong> The mean age of the patients was 60.56&plusmn;16.32 years. The most common symptoms on admission were dyspnea (79.1%), coughing (77.3%) and fever (73.1%). The common radiological pattern was multifocal patchy ground-glass infiltration. The patients were followed-up for 8 weeks by phone call. During discharge, 24.8% of the patients had no symptoms, the common residue symptoms were weakness and malaise (48.2%), dyspnea (38.7%), coughing (20.4%), hyposmia (18.5%). On week 8, 74.6% of the patients had no symptom. Moreover, 47.14% of CT scan results improved after 4 weeks and 43.39% after 8 weeks. <strong>Conclusion</strong>: Further follow-up studies are required to determine other detrimental illnesses related to the disease and how vaccination against COVID-19 can affect them. COVID-19, follow-up, discharged patient, clinical outcome, radiologic outcome 1 8 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-3363-2&slc_lang=en&sid=1 Mehrangiz Zangeneh zangeneh4@yahoo.com 0000-0001-7673-4287 No Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Treata Private Hospital, Tehran, Iran; C. Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran Yasamin Khosravani-Nezhad jasminegoli@yahoo.com No Medical Student, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Mohsen Alijani mhs_alijani@yahoo.com No Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Behnam Farhoodi b_farhoudi@yahoo.com No Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Hamid-Reza Massumi-Naini massumi44@yahoo.com No Department of Internal Medicine, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Seyed-Davar Siadat d.siadat@gmail.com 0000-0002-6892-5603 No Department of Mycobacteriology and Pulmonary Research, Microbiology Research Center, Pasteur Institute of Iran, Tehran, Iran Masoomeh Mesgarian m88mesgarian@gmail.com Yes Department of Infectious Diseases, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran