en Immune responses tovaccines Immune responses tovaccines Short communication Short communication <strong>Introduction:</strong> <em>Peste des petits</em> ruminants (PPR) or goat plague is a highly contagious viral disease of small ruminants such as sheep and goats with 90% and 100% morbidity and mortality, respectively. This study was aimed at assessing <em>Peste des petits</em> Ruminants Virus (PPRV) specific antibodies in vaccinated pregnant ewes and subsequently the passive immunity in their lambs. <strong>Methods:</strong> Seventeen apparently healthy sheep (8 pregnant and 9 non pregnant), 2-3 years old and kept under semi-intensive system of management were used. Ewes were vaccinated with the National Veterinary Research Institute PPR vaccine Nigeria strain 75/1 with a virus titre of 10³ Tissue Culture Infectious Dose (TCID). Serum Samples were collected from all the sheep before and after vaccination at interval of two weeks for a period of seven months. The resultant (8) lambs were given birth to, blood sample were collected for four month and sera samples were examined using Competitive ELISA (c-ELISA) for the presence of specific PPR-N antibodies.&nbsp; <strong>Results:</strong> The analysed result showed that there was significant difference&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;(<em>P</em> < 0.05) in the mean PPRV-N specific antibody c-ELISA values (0-13) before vaccination and the percentage competition protective values (> 50%). However, no significant difference (<em>p</em> > 0.05) post-vaccination in both pregnant and non-pregnant ewes was observed throughout the period of the study with mean PPRV-N specific c-ELISA antibodies of 72-86 and 52-86, respectively. The mean PPRV-N specific antibodies values were maintained within the protective value (> 50 %). The result of this study also showed that there was significant difference (<em>P</em> < 0.05) with mean PPRV-N specific c-ELISA antibodies (17.3-29.4; 87.5%) of lambs born to vaccinated pregnant Yankassa ewes from 8 weeks. <strong>Conclusion:</strong> This study showed that vaccination does not affect pregnancy with Nigeria 75/1 strain of PPR vaccine in ewes as there was no record of abortion. There was a rapid PPR maternal antibody decay in lambs from the 8th week of age as it was observed that at age 10 weeks, only 37.5 % of the lambs had protective titre. It is therefore recommended that lambs can be vaccinated at 9^th week to avoid the window of susceptibility to PPR virus infection. Peste des petits ruminants, antibodies, pregnant ewe, Vaccination 47 51 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-2956-1&slc_lang=en&sid=1 Olushola olaolu olaoluolushola@gmail.com Yes Department of Veterinary Microbiology, Ahmadu Bello University, Zaria Haruna Kazeem haruna_kazeem@yahoo.com No Department of Veterinary Microbiology, Ahmadu Bello University, Zaria Jibril Adamu jiboadm@yahoo.com No Department of Veterinary Microbiology, Ahmadu Bello University, Zaria Talatu Markus talatupmarkus@gmail.com No Department of Veterinary Microbiology, Ahmadu Bello University, Zaria Timothy Woma womaty@gmail.com No Viral Research Division, National Veterinary Research Institute, Vom