Vaccine Research
Vaccine Research
vacres
Medical Sciences
http://vacres.pasteur.ac.ir
1
admin
2383-2819
2423-4923
10.61186/vacres
en
jalali
1399
3
1
gregorian
2020
6
1
7
1
online
1
fulltext
en
In silico study to predict and characterize of SARS CoV 2 Surface glycoprotein
Protein modeling
Protein modeling
Short communication
Short communication
<strong>Introduction:</strong> Coronavirus family member SARS- CoV-2 is a current worldwide threat. It enters into the epithelium membrane of respiratory tract with the help of its antigenic spike proteins and cause Coronavirus disease 2019 (COVID -19). <strong>Methods:</strong> Considering SARS- CoV-2 a potent vaccine or diagnostic candidate, a bioinformatical study was done to determine its structure homology modeling, physiological properties and structure validation with presence of antigenic sites. <strong>Results: </strong>The surface glycoprotein of SARS-CoV-2 was found to be a stable protein with stereochemically good structure. It also contains 65 antigenic sites. <strong>Conclusion:</strong> The present study suggests further wet-lab research to develop a vaccine or diagnostic kit using this promising surface glycoprotein.
COVID-19,6VSB,corona vaccine,Spike protein,Glycoprotein
10
16
http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-1019-1&slc_lang=en&sid=1
Avnish
Kumar
avnishkumar81@gmail.com