Vaccine Research
Vaccine Research
vacres
Medical Sciences
http://vacres.pasteur.ac.ir
1
admin
2383-2819
2423-4923
10.52547/vacres
en
jalali
1395
8
1
gregorian
2016
11
1
3
3
online
1
fulltext
fa
Lactococcus lactis as a live delivery vector
Review article
Review article
<p dir="ltr" style="text-align: justify;">Mucosal surfaces of the body provide a universal entry portal for all known and emerging infectious pathogenic microbes. Therefore, it seems that special vaccination strategies are needed for vaccines that can hinder the entry capability of pathogenic microbes through the mucosal surfaces. Lactic acid bacteria are widely used in the food industry and are presently applied as delivery vehicles in many biological investigations. Among these bacteria, <em>Lactococcus lactis </em>is considered as a promising candidate for mucosal live vaccines to be used as an antigen delivery vector. This is an attractive alternative and a safer vaccination strategy against the pathogens, compared to other conventional methods. In this review, we summarized the applications of <em>L. lactis</em> as a mucosal vector of vaccine delivery for heterologous expression of proteins and its applications in biotechnology. </p>
Lactococcus lactis, Live vector, Live delivery vaccines, Mucosal vaccines.
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43
http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-1-27&slc_lang=fa&sid=1
M
Azizpour
maryam.azizpour@gmail.com
10031947532846002293
10031947532846002293
No
Department of Microbiology, Arak branch, Islamic Azad University, Arak, Iran and Young Researchers and Elite Club, Arak Branch, Islamic Azad University, Arak, Iran.
SD
Hosseini
hosseinida@yahoo.com
10031947532846002294
10031947532846002294
Yes
Razi vaccine and serum Research institute, Arak Branch, Arak, Iran.
P
Jafari
10031947532846002295
10031947532846002295
No
Department of Microbiology, Islamic Azad University, Arak Branch, Arak, Iran.
N
Akbary
10031947532846002296
10031947532846002296
No
Department of Microbiology, Islamic Azad University, Arak Branch, Arak, Iran.