Vaccine Research
Vaccine Research
vacres
Medical Sciences
http://vacres.pasteur.ac.ir
1
admin
2383-2819
2423-4923
10.52547/vacres
en
jalali
1393
8
1
gregorian
2014
11
1
1
2
online
1
fulltext
en
Effective Dendritic Cell-based Immunotherapeutic Vaccines for Acute Myeloid Leukemia (AML)
Original article
Original article
<span style="FONT-FAMILY: "Times New Roman",serif FONT-SIZE: 11pt mso-ascii-theme-font: major-bidi mso-fareast-font-family: 'Times New Roman' mso-hansi-theme-font: major-bidi mso-bidi-theme-font: major-bidi mso-ansi-language: EN-US mso-fareast-language: EN-US mso-bidi-language: AR-SA">Acute myeloid leukemia (AML) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. Leukemic stem cells are thought to<font face="Times New Roman"><span style="COLOR: red"><font size="3"> </font></span>form the majority of a cell population in minimal residual diseases (MRDs) which are resistant to current chemotherapeutic regimens and mediate disease relapse. Current therapeutic vaccine strategies have developed to mount effective anti-leukemic immunity and eradicate the MRDs. Dendritic cells (DCs) are the most professional antigen-presenting cells to elicit efficient anti-leukemic immune responses. In this review article, we present<span style="COLOR: red"><font size="3"> </font></span>the possibility of generating AML blast-targeted DCs, especially leukemia-derived DCs and their appropriate maturation protocols and particularly the synergistic effects of TLR agonists. We also discuss about the <i>in vitro</i> evaluation of the generated DCs, some reported outcomes of DC-based clinical trials as well as the possibility of combination therapy to improve the efficacy of DC-based vaccines in AML patients.</font></span>
AML-DC, DC-based cancer vaccine, acute myeloid leukemia (AML)
16
23
http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-27-13&slc_lang=en&sid=1
Maryam
Nourizadeh
10031947532846001099
10031947532846001099
No
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Jamshid
Hadjati
hajatij@sina.tums.ac.ir
10031947532846001100
10031947532846001100
Yes
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran