en Prophylactic and therapeutic, and plant-based vaccines Prophylactic and therapeutic, and plant-based vaccines Review article Review article <strong>Introduction:</strong> The tick-borne encephalitis (TBE) virus causes a dangerous neuroinfection in humans can serve as a model for studying the mechanisms of interaction of pathogens with specific antibodies during active and passive immunization. Several commercial vaccines are currently used against TBE. This review analyzes long-term studies aimed at explaining the active and passive efficacy of specific immunoprophylaxis against TBE. <strong>Methods:</strong> The effectiveness of &quot;Encepur&reg; adult&quot; TBE vaccine has been studied in terms of seroconversion and strength of the immune response by serological reactions, namely IFA, ELISA and neutralizing were reviewed. <strong>Results:</strong> Rapid elimination of the virus (after 1-2 days) can occur in vaccinated individuals with antibodies in titers of more than 1: 400. Persons with antibodies in titers of 1: 100 and 1: 200, most likely, should be offered mandatory revaccination. It should also take into account the duration of the retention of post-vaccination antibodies. <strong>Conclusion:</strong> In the year of TBE vaccination, the immune response was at a high level and practically did not differ. A particularly high level of immune protection was observed in persons who were vaccinated by a combination of TBE vaccines of various producers. tick-borne encephalitis virus, vaccine prevention, passive immunization 11 17 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-4704-1&slc_lang=en&sid=1 Galina Leonova galinaleon41@gmail.com 0000-0001-6387-1127 Yes Laboratory of Natural Focal Infections of the FGBNU “Research Institute of Epidemiology and Microbiology named after G.P. Somova