Vaccine Research
Vaccine Research
vacres
Medical Sciences
http://vacres.pasteur.ac.ir
1
admin
2383-2819
2423-4923
10.61186/vacres
en
jalali
1398
3
1
gregorian
2019
6
1
6
1
online
1
fulltext
fa
Seroepidemiology of Pertussis in a Set of Under One Year Old Iranian Children
Infectious diseases
Infectious diseases
پژوهشي
Research
<div style="text-align: justify;"><strong>Introduction:</strong> Pertussis or whooping cough is one of the vaccine preventable diseases. The purpose of this study was to<br>
evaluate the seroepidemiology of pertussis in two groups of children (i.e. under 2 months and 2-12 months old) who<br>
had been admitted to Tehran Children Hospital. <strong>Methods:</strong> Sampling from the children was done along with completing<br>
a questionnaire including demographic information, clinical symptoms and the history of the parents coughing. The<br>
levels of IgG-Ptx antibody were then measured using the children's sera. <strong>Results:</strong> Overall, 10.8% of the children were<br>
not immune, 78.3% were immune, and 10.9% had recent pertussis infections. Moreover, 19.4% of the female and<br>
13.1% of the male subjects had the infection. In the age group less than two months, 16.6% were infected. The<br>
likelihood of new infection among the children less than 2 months old was 1.2 times higher than the control group (P <<br>
0.004). Fifty percent of the children who were diagnosed with cyanosis in their clinical examinations had a recent<br>
infection (P <0.001). <strong>Conclusion:</strong> Pertussis appears to be endemic in Iran with children under one year old being at<br>
high risk of the infection. In this regard, maternal vaccination against pertussis for conferring passive immunity to the<br>
newborns could be considered as a protection measure. </div>
Pertussis, IgG-ptx, seroepidemiology
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http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-338-2&slc_lang=fa&sid=1
Ali
Badamchi
badamchiy2@gmail.com