en Vaccine development, efficacy and safety evaluation Vaccine development, efficacy and safety evaluation Original article Original article The 100-year-old Pasteur Institute of Iran is a research, manufacturing, and educational institute that aims to provide public health. It has taken great steps towards producing vaccines in Iran. The institute has played an important role in controlling infectious diseases in Iran by producing a great number of vaccines such as smallpox, cholera, Bacillus Calmette&ndash;Gu&eacute;rin (BCG), and recombinant hepatitis B along with infectious disease control programs and diagnostic laboratories. The institute is currently pursuing a program to develop its production lines for human polysaccharide-conjugate vaccines and viral vaccines for the health system of Iran.<br> This paper reviews manufacturing activities of this institute over the past 100 years.<br> &nbsp; ,Pasteur Institute of Iran,Vaccin,Smallpox,Hepatitis B 33 42 http://vacres.pasteur.ac.ir/browse.php?a_code=A-10-589-1&slc_lang=en&sid=1 Sholeh Maslehat sholeh.maslehat@gmail.com No Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran Delaram Doroud ddoroud@yahoo.co.uk 0000-0003-4167-9921 No Production and research complex, Pasteur Institute of Iran, Tehran, Iran ehsan mostafavi mostafaviehsan@gmail.com 0000-0002-1997-517X Yes Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran