TY - JOUR T1 - In silico study to predict and characterize of SARS CoV 2 Surface glycoprotein TT - JF - vacres JO - vacres VL - 7 IS - 1 UR - http://vacres.pasteur.ac.ir/article-1-179-en.html Y1 - 2020 SP - 10 EP - 16 KW - COVID-19 KW - 6VSB KW - corona vaccine KW - Spike protein KW - Glycoprotein N2 - Introduction: Coronavirus family member SARS- CoV-2 is a current worldwide threat. It enters into the epithelium membrane of respiratory tract with the help of its antigenic spike proteins and cause Coronavirus disease 2019 (COVID -19). Methods: Considering SARS- CoV-2 a potent vaccine or diagnostic candidate, a bioinformatical study was done to determine its structure homology modeling, physiological properties and structure validation with presence of antigenic sites. Results: The surface glycoprotein of SARS-CoV-2 was found to be a stable protein with stereochemically good structure. It also contains 65 antigenic sites. Conclusion: The present study suggests further wet-lab research to develop a vaccine or diagnostic kit using this promising surface glycoprotein. M3 10.29252/vacres.7.1.10 ER -