TY - JOUR JF - vacres JO - vacres VL - 8 IS - 1 PY - 2021 Y1 - 2021/6/01 TI - Comparative Study of AEFI of Hepatitis B Vaccine between Iran Ministry of Health CDC and VAERS Data during 2015 to 2017 TT - N2 - Introduction: Hepatitis B Vaccine (HBV) is a safe and effective vaccine that is nowadays recommended for all infants at birth as well as adults who could be exposed to hepatitis B virus. HBV can provide lifetime protection against hepatitis B virus infection. Despite its highly effective disease prevention, HBV can also cause adverse effects for the vaccinated population. A vast majority of Iran's population are vaccinated with recombinant hepatitis B vaccine (rHBV) which is manufactured by the Production and Research Complex of Pasteur Institute of Iran. Methods: The reported adverse events of rHBV, obtained from Diseases Management Center of Iran’s Ministry of Health were compared with those in The Vaccine Adverse Event Reporting System (VAERS, a United States program for vaccine safety, co-managed by the U.S. Centers for Disease Control and Prevention) during 2015 to 2017. Results: The most common adverse events after administration of rHBV, manufactured by Pasteur Institute of Iran was injection site reactions and no life threatening adverse event was observed. Conclusion: Despite reports by VAERS indicating that HBV can cause adverse events and even death in the United States, no such adverse effects were observed in rHBV manufactured in Iran. SP - 52 EP - 59 AU - Hozouri, Hamidreza AU - Shamsian, Alireza AU - Aghasadeghi, Mohammadreza AU - Doroud, Delaram AD - Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran, Iran. Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran. KW - AEFI KW - rHBV KW - VAERS KW - CDC KW - Pasteur Institute of Iran UR - http://vacres.pasteur.ac.ir/article-1-275-en.html DO - 10.52547/vacres.8.1.52 ER -