دوره 10، شماره 2 - ( 10-1402 )
جلد 10 شماره 2 صفحات 59-56 |
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Sheikhpour M, Sakhi H. Carbon Nanotube-Based Nanovaccines in Lung Cancer Immunotherapy. vacres 2023; 10 (2) :56-59
URL: http://vacres.pasteur.ac.ir/article-1-366-fa.html
URL: http://vacres.pasteur.ac.ir/article-1-366-fa.html
Carbon Nanotube-Based Nanovaccines in Lung Cancer Immunotherapy. Vaccine Research. 1402; 10 (2) :56-59
چکیده: (89 مشاهده)
Conventional lung cancer therapies—including surgery, chemotherapy, and radiotherapy—are often limited by insufficient efficacy and significant adverse effects. In response, cancer immunotherapy, particularly vaccine-based approaches, has emerged as a promising strategy to improve outcomes. Carbon nanotubes (CNTs) represent a versatile nanoplatform capable of efficiently delivering antigens, adjuvants, and therapeutic agents, making them attractive candidates for nanovaccine development. This review examines the role of CNT-based nanovaccines in lung cancer immunotherapy, focusing on their mechanisms of action and therapeutic potential. Evidence indicates that CNT nanovaccines enhance antitumor immunity by promoting dendritic cell maturation, stimulating robust humoral and cellular immune responses, and reprogramming the immunosuppressive tumor microenvironment toward an immunopermissive state. Despite these promising preclinical results, clinical translation requires further optimization of CNT design and functionalization, alongside comprehensive in vivo evaluation of immunogenicity, biodistribution, and safety profiles. Overall, CNT-based nanovaccines hold considerable potential to advance lung cancer immunotherapy, though targeted research is needed to bridge the gap between experimental promise and clinical application.
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