دوره 7، شماره 2 - ( 9-1399 )                   جلد 7 شماره 2 صفحات 74-79 | برگشت به فهرست نسخه ها


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Nazari M, Badmasti F. In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate. vacres. 2020; 7 (2) :74-79
URL: http://vacres.pasteur.ac.ir/article-1-242-fa.html
In Silico Evaluation of a Mutant Toxic Shock Syndrome Toxin-1 (TSST-1) of Staphylococcus aureus as a Putative Vaccine Candidate. Vaccine Research. 1399; 7 (2) :74-79

URL: http://vacres.pasteur.ac.ir/article-1-242-fa.html


چکیده:   (228 مشاهده)
Introduction: The development of a vaccine against Staphylococcus aureus has proven to be much more difficult than expected. In this study, we considered and analyzed a mutant Toxic Shock Syndrome Toxin-1 (TSST-1) as a potential vaccine candidate. Methods: An NCBI sequence of TSST-1 was analyzed bioinformatically by online tools such as Ensemble and Pubmlst. The protein sequence of TSST-1 was similarly analysed by Expasy ProtParam, Phyre2 and Vaxign databases. The protein functional class was predicted by VICMpred database while the B- and T-cell epitopes were predicted by IEDB and BepiPred tools. The 3D structure was predicted by LOMETS, QMEAN, ProSA-web and ElliPro. The conservation of the epitopes was evaluated by ConSurf tool.  Results: In silico analyses showed that this protein is present in high-prevalence sequence types of circulating clinical strains. It appears that TSST-1 has conserved liner and conformational B-cell epitopes. In addition, there are four potent of T-cell epitopes in this protein. Conclusion: This in silico data indicated that TSST-1 (and especially amino acid residues 81-221) is a promising vaccine target against S. aureus.
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نوع مطالعه: پژوهشي | موضوع مقاله: Infectious diseases
دریافت: 1400/2/5 | پذیرش: 1400/4/1 | انتشار: 1400/7/4

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