Introduction: To understand the effects of COVID-19 vaccines it would be essential to have knowledge about the effects of the disease during the time that vaccines were unavailable. Hence, we tracked the clinical outcomes of Iranian COVID-19 patients during Feb 19th till May 1st 2020 by a longitudinal follow-up study of patients discharged from a university hospital in Iran. Methods: Demographic, clinical, and paraclinical data (chest CT scan imaging, and RT-PCR tests) of 139 patients were collected at the admission time. Preliminary clinical, radiological, laboratory, treatment information, and follow up results were extracted and collected from patients' records. Results: The mean age of the patients was 60.56±16.32 years. The most common symptoms on admission were dyspnea (79.1%), coughing (77.3%) and fever (73.1%). The common radiological pattern was multifocal patchy ground-glass infiltration. The patients were followed-up for 8 weeks by phone call. During discharge, 24.8% of the patients had no symptoms, the common residue symptoms were weakness and malaise (48.2%), dyspnea (38.7%), coughing (20.4%), hyposmia (18.5%). On week 8, 74.6% of the patients had no symptom. Moreover, 47.14% of CT scan results improved after 4 weeks and 43.39% after 8 weeks. Conclusion: Further follow-up studies are required to determine other detrimental illnesses related to the disease and how vaccination against COVID-19 can affect them.

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