:: دوره 7، شماره 1 - ( 4-1399 ) ::
جلد 7 شماره 1 صفحات 25-37 برگشت به فهرست نسخه ها
The Potential of Self-amplifying RNA Vaccines for Infectious Diseases and COVID-19
چکیده:   (302 مشاهده)
In addition to conventional vaccine development for infectious diseases, nucleic acid-based vaccine approaches have recently been presented as serious alternatives to previously used strategies based on live attenuated virus particles and subunit vaccines. Particularly, RNA-based vaccines have proven attractive. In this context, immunization with messenger RNA (mRNA) has provided strong immune responses and protection against challenges with lethal doses of pathogenic viruses in vaccinated animals. Alternatively, the efficient RNA replication mechanism provided by self-amplifying RNA (saRNA) viruses has been utilized. Enhanced immune responses with reduced doses required for immunization has been obtained in comparison to conventional mRNA administration. The rapid spread and destruction caused by the COVID-19 pandemic has substantially accelerated the demand for the development of robust and efficient vaccines against SARS-CoV-2. Both mRNA- and saRNA-based COVID-19 vaccine candidates are currently in human clinical trials.
متن کامل [PDF 617 kb]   (96 دریافت)    
نوع مطالعه: Review article | موضوع مقاله: Vaccine development, efficacy and safety evaluation
دریافت: 1399/4/27 | پذیرش: 1399/5/11 | انتشار: 1399/7/3



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دوره 7، شماره 1 - ( 4-1399 ) برگشت به فهرست نسخه ها