The amount of multidrug-resistant (MDR) strains, especially methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, as frequent causes of nosocomial and device-related infections have increased. Biofilm formation is an essential requisite in staphylococcal pathogenicity. It is considered as a bacterial surveillance, antibiotic resistance, and transition of antibiotic resistance genes factor.  Therefore, biofilm-related macromolecules have been suggested as putative new vaccine candidates to combat staphylococcal infections. Based on the MEDLINE and Google scholar databases, some Staphylococci macromolecules are involved in the biofilm formation process and have been reviewed as putative vaccines. Based on experiments, common staphylococcus antigens could prevent the progress of the caused diseases by this genus. Moreover, considering related stages in biofilm formation, a multivalent putative vaccine (protein and polysaccharide) candidate could be enhancing the eradication chance of aforementioned bacterial families.

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